Current Studies

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Participate in Research

Our team of professionals are trained to conduct clinical trials for people who want to quit smoking.

Our trials test medications, behavioral approaches and various combinations of both in an attempt to find the most effective smoking cessation treatment. Our staff is also trained to conduct behavioral counseling.



The DUAL Study

The DUAL Study is a research study for cigarette smokers. The research study explores the potential of reducing smokers’ addiction to combustible cigarettes by reducing the nicotine content of tobacco. Study participants will also use e-cigarettes to model real world environments where e-cigarette use is growing. No research drug will be given, but you will be asked to use reduced nicotine cigarettes and an e-cigarette during the course of this study.


The purpose of this research study is:

  • To gather information on the number of reduced nicotine cigarettes smoked per day
  • To see at what point smokers can first detect nicotine and when smokers can detect a drop in nicotine
  • To determine if e-cigarette use is related to the dual use of combustible cigarettes

1What are the criteria to participate?
  • Between 21-65 years old
  • No intention of quitting smoking in the next 90 days
  • Smokes on average 4 days a week over the past year
  • Willing to use reduced nicotine cigarettes and an e-cigarette, both provided by Rose Research
  • Not currently diagnosed with any serious medical conditions
  • On a daily basis, does NOT use chewing tobacco, cigars, pipes, hookahs, or e-cigarettes
  • Has not used nicotine replacement therapy or other smoking cessation product in the last 30 days
  • Has a smartphone with data and text capabilities
2How long is the study?
Your total participation in this study will last 14-16 weeks and will involve 9 total visits. The first visit will last approximately 2-3 hours; Visits 2 and 3 will last approximately 2-3 hours; Visit 4 will last approximately 1 hour; Visit 5 will last about 2 hours, and Visits 6, 7, 8, and 9 will last approximately 3 hours.
3Will I be compensated for my participation in this study?
For your time and inconvenience related to your participation in this study, you will be paid up to a potential maximum of $980 if you complete this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete. As a part of your total compensation, you will also receive $20 each week that you receive SMS questionnaires.
4Who is sponsoring the study?
The study is being conducted by the Rose Research Center and is funded by a grant from the National Institutes of Health.

The RECON Study

The RECON study is a research study for cigarette smokers who want to switch to e-cigarettes. The purpose of this research study is to see if using an e-cigarette right before smoking helps to satisfy your craving for a cigarette and helps you switch to using only an e-cigarette.

1What are the criteria to participate?
  • Between the age of 21-65
  • Desire to switch from combustible cigarettes to e-cigarettes
  • Currently smoke 10 or more cigarettes per day
  • Able to pass a urine drug test
  • No current serious medical conditions
  • No use of other tobacco products in the last 14 days (including cigars, pipes, hookahs, e-cigarettes, or nicotine replacement therapy)
2How long is the study?
Your participation in this study will last approximately 14 weeks and will include seven visits to the study center. The first Screening Session (V1) will last approximately two to three hours, and all other study visits will last approximately one hour.
3Will I be compensated for my participation in this study?
You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive $25 for completing Study Visit 1
  • You will receive $75 for each completed visit; Study Visit 2 through Study Visit 7
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of questions before you receive your next text message.
4Who is sponsoring the study?
The study is being funded by the Foundation for a Smoke-Free World.

The EVAR Study

The purpose of this research study is to see if using an e-cigarette with varenicline (also called Chantix) helps you switch to using only an e-cigarette.

1What are the criteria to participate?
  • Between the age of 21-65
  • Desire to switch to an e-cigarette
  • Willingness to take study medications as directed
  • Currently smoke 10 or more cigarettes per day
  • Able to pass a urine drug test
  • No current serious medical conditions
  • No use of other tobacco products in the last 14 days (including cigars, pipes, hookahs, e-cigarettes, or nicotine replacement therapy.)
2How long is the study?
Your participation in this study will last about 14-16 weeks and will include seven visits to the study center. This Screening Session (Study Visit 1) will last approximately two to three hours, and all other study visits will last approximately one hour.
3Will I be compensated for my participation in this study?
You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive $25 for completing Study Visit 1
  • You will receive $75 for each completed visit; Study Visit 2 through Study Visit 7 ($450 total)
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of the questions before you receive your next text message.
4Who is sponsoring the study?
The study is being funded by the Foundation for a Smoke-Free World.

The BUZONE Study

The BUZONE Study is a research study for cigarette smokers who want to switch to e-cigarettes. The purpose of this research study is to see if using an e-cigarette in combination with two medications (bupropion and zonisamide) helps you switch to using only an e-cigarette. Zonisamide is a drug approved by the United States Food and Drug Administration (FDA) for treatment of seizures. Bupropion (also known as Zyban) is a drug approved by the FDA for use as an aid to quit smoking.

1What are the criteria to participate?
  • Between the age of 21-65
  • Desire to switch to an e-cigarette
  • Willingness to take study medications as directed
  • Currently smoke 10 or more cigarettes per day
  • Able to pass a urine drug test
  • No current serious medical conditions
  • No use of other tobacco products in the last 14 days (including cigars, pipes, hookahs, e-cigarettes, or nicotine replacement therapy.)
2How long is the study?
Your participation in this study will last about 14-16 weeks and will include seven visits to the study center. This Screening Session (Study Visit 1) will last approximately two to three hours, and all other study visits will last approximately one hour.
3Will I be compensated for my participation in this study?
You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive $25 for completing Study Visit 1
  • You will receive $75 for each completed visit; Study Visit 2 through Study Visit 7 ($450 total)
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of the questions before you receive your next text message. Text messages will be sent once per day for approximately 90 days ($450 total)
4Who is sponsoring the study?
The study is being funded by the Foundation for a Smoke-Free World.

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For Future Studies

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Participant information is maintained in a volunteer database system and retained for future studies as they become available. Pertinent information is confidentially kept on file to aid in selecting highly qualified candidates for research studies.



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Why should I participate?

Participants may gain access to new research treatments before they are widely available.

Additionally, participants are compensated for their time and receive study-related products and medications at no cost. You may be among the first to benefit if the approach being studied is found to be helpful.


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