Current Studies

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Our team of professionals are trained to conduct clinical trials for people who want to quit smoking.

Our trials test medications, behavioral approaches and various combinations of both in an attempt to find the most effective smoking cessation treatment. Our staff is also trained to conduct behavioral counseling.



The DUAL Study

The DUAL Study is a research study for cigarette smokers. The research study explores the potential of reducing smokers’ addiction to combustible cigarettes by reducing the nicotine content of tobacco. Study participants will also use e-cigarettes to model real world environments where e-cigarette use is growing. No research drug will be given, but you will be asked to use reduced nicotine cigarettes and an e-cigarette during the course of this study.


The purpose of this research study is:

  • To gather information on the number of reduced nicotine cigarettes smoked per day
  • To see at what point smokers can first detect nicotine and when smokers can detect a drop in nicotine
  • To determine if e-cigarette use is related to the dual use of combustible cigarettes

DUAL FAQ

1What are the criteria to participate?
  • Between 21-65 years old
  • No intention of quitting smoking in the next 90 days
  • Smokes on average 4 days a week over the past year
  • Willing to use reduced nicotine cigarettes and an e-cigarette, both provided by Rose Research
  • Not currently diagnosed with any serious medical conditions
  • On a daily basis, does NOT use chewing tobacco, cigars, pipes, hookahs, or e-cigarettes
  • Has not used nicotine replacement therapy or other smoking cessation product in the last 30 days
  • Has a smartphone with data and text capabilities
2How long is the study?
Your total participation in this study will last 14-16 weeks and will involve 9 total visits. The first visit will last approximately 2-3 hours; Visits 2 and 3 will last approximately 2-3 hours; Visit 4 will last approximately 1 hour; Visit 5 will last about 2 hours, and Visits 6, 7, 8, and 9 will last approximately 3 hours.
3Will I be compensated for my participation in this study?
For your time and inconvenience related to your participation in this study, you will be paid up to a potential maximum of $980 if you complete this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete. As a part of your total compensation, you will also receive $20 each week that you receive SMS questionnaires.
4Who is sponsoring the study?
The study is being conducted by the Rose Research Center and is funded by a grant from the National Institutes of Health.


The BRST Study

The purpose of this research study is to have you document your experience when taking nicotine sublingual fast dissolving lozenges (1 mg and 2 mg). Two hours apart, a tablet will be placed under your tongue until it dissolves, and you will complete questionnaires about the experience.


BRST FAQ

1What are the criteria to participate?
  • Between 21-60 years old
  • Smokes at least 10 cigarettes per day
  • Typically smokes within 30 minutes of waking up
2How long is the study?
Your participation in this study will last about 7-8 hours. The virtual screening procedures will take approximately 1 hour. The On-Site Visit will last approximately 6-7 hours.
3Will I be compensated for my participation in this study?
You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive a $10 Amazon gift card for completing this virtual screening.
  • You will receive $15 for completing the on-site screening procedures.
  • You will receive $575 for completing the on-site study visit.
  • 4Who is funding the study?
    The study is being funded by Nicotine BRST LLC


    The Embera Study

    The purpose of the Embera study is to see if using a combination of two medications may help you quit smoking. Both medications (metyrapone and oxazepam) are Food and Drug Administration (FDA) approved, but not specifically to help people quit smoking. Metyrapone is a drug used to test hypothalamic-pituitary ACTH function and oxazepam is a drug used to treat anxiety or alcohol withdrawal symptoms. The use of these drugs together is investigational and has not been approved by the FDA.


    Embera FAQ

    1What are the criteria to participate?
    • Between 21-65 years old and able to pass a urine drug screening.
    • Smokes at least 10 cigarettes per day.
    • Are not currently diagnosed with any serious medical or psychological conditions.
    • Have not used any electronic cigarettes, vapes, chewing tobacco, cigars, pipes, hookahs, or nicotine replacement therapy (nicotine patches, lozenges, gum, etc.) in the last 2 weeks.
    • Because these two drugs are not FDA approved to be used together, females must be unable to become pregnant during the course of this study. This means women must be post-menopausal or surgically sterile.
    • Must not have recently used any of the following: illegal drugs, investigation drugs, SSRIs, antidepressants, antipsychotics, opiates, biotin products, glucocorticoids (oral, inhaled, or topical), or joint injections.
    2How long is the study?
    Your participation in this study will last about 16-17 weeks and will include twelve (12) visits to the study center. This Screening Session (Study Visit 1) and Study Visit 3 will last approximately two to three hours, and all other study visits will last approximately one hour.
    3Will I be compensated for my participation in this study?
    Yes. You will be compensated up to $2,225 plus $5/day for completing daily surveys for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive $25 for completing Study Visit 1.
  • You will receive $100 for completing Study Visit 2.
  • You will receive $150 for completing Study Visit 3.
  • You will receive $175 for completing Study Visit 4 through Study Visit 6 ($525 total).
  • You will receive $200 for completing Study Visit 7 through Study Visit 10 ($800 total).
  • You will receive $250 for completing Study Visit 11 and Study Visit 12 ($500 total).
  • You will receive $25 for participating in telemedicine contacts between visits ($125 total).
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of the questions before you receive your next text message.
  • 4Who is funding the study?
    The study is being funded by Embera NeuroTherapeutics. Inc. The study investigator and research staff are being paid by them to conduct this study. The Foundation for a Smoke-Free World paid for the manufacturing of the study drug. The Foundation for a Smoke-Free World is an independent non-profit organization that receives funding from Philip Morris International (a company which manufactures cigarettes).


    The COCO Study

    The main purpose of this research study is to compare the measured amount of carbon monoxide (CO) in your exhaled breath between two different CO monitors and compare these to the amount of carbon monoxide in your blood measured directly from a sample of blood from your vein. Both of the CO monitors being used in this study are approved by the United States Food and Drug Administration (FDA). Another purpose of this research study is to evaluate a new mobile app called eResearch. This app was developed by Rose Research Center to conduct remote research. .

    COCO FAQ

    1What are the criteria to participate?
    • Between 21-65 years old
    • Able to pass a urine drug screen
    • Daily cigarette smoker
    • Willing to use reduced nicotine cigarettes and an e-cigarette, both provided by Rose Research
    • No intention of quitting smoking in the next 30 days.
    • Must not have recently used any of the following: illegal drugs, investigational drugs, or chronic opioid use.
    2How long is the study?
    Your participation in this study will last about 1-2 weeks and will include a virtual visit and two in-person visits to the study center. The virtual Screening Session will last approximately one hour and will be done through a virtual meeting. Your first visit to our Center will last one to two hours and the other visit will last 15-20 minutes. You will also be asked to complete tasks from home using the app during the time between visits. These daily tasks should take about 15-30 minutes.
    3Will I be compensated for my participation in this study?
    You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits and tasks you do complete according to the following schedule:
  • You will receive a $10 Amazon gift card for completing this virtual screening.
  • You will receive $15 for completing the on-site screening procedures.
  • You will receive $100 for completing the first study visit.
  • You will receive $25 a day for completing tasks in eResearch. In order to receive this compensation, you will need to compete the task and respond to the questions in the workbook. All of these payments except one will be processed at your final visit. One of the tasks your complete in eResearch will prompt an immediate payment through the app.
  • If you are randomly selected to take home a screening kit you will be compensated an additional $25. This payment will be processed at your final visit.
  • You will receive $10 for completing the final study visit.
  • You will receive an additional $10 for completing the final task that occurs after the final visit.
  • 4Who is funding the study?
    The study is being funded by a grant from the Foundation for a Smoke-Free World. The study investigator and research staff are being paid to conduct this study. The Foundation for a Smoke-Free World is an independent non-profit organization that receives funding from Philip Morris International (a company which manufactures cigarettes).

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    For Future Studies

    Fill out our form below for more information

    Participant information is maintained in a volunteer database system and retained for future studies as they become available. Pertinent information is confidentially kept on file to aid in selecting highly qualified candidates for research studies.



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    Why should I participate?

    Participants may gain access to new research treatments before they are widely available.

    Additionally, participants are compensated for their time and receive study-related products and medications at no cost. You may be among the first to benefit if the approach being studied is found to be helpful.


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