Participate in Research

Our team of professionals are trained to conduct clinical trials for people who want to quit smoking.

Our trials test medications, behavioral approaches and various combinations of both in an attempt to find the most effective smoking cessation treatment. Our staff is also trained to conduct behavioral counseling.

The BuZonE RCT Study

The main purpose of this research study is to see if taking a combination of zonisamide and bupropion for a short time helps you switch to using only an e-cigarette. Zonisamide is a drug approved by the United States Food and Drug Administration (FDA) for treatment of seizures. Bupropion (also known as Zyban) is a drug approved by the FDA for use as an aid to quit smoking (but not for switching from combustible cigarettes to e-cigarettes). The use of the combination of zonisamide and bupropion is not FDA approved for the purpose of switching from combustible cigarettes to e-cigarette use and is therefore considered investigational for this study.


1What are the criteria to participate?
  • Between 21-65 years old
  • Desire to switch to an e-cigarette
  • Willingness to take study medications as directed
  • Currently smoke 10 or more cigarettes per day
  • Able to pass a urine drug test
  • No current serious medical conditions
  • No use of other tobacco products in the last 14 days​
2How long is the study?
Your participation in this study will last about 13-14 weeks and will include seven visits to the study center. The initial on-site Screening Visit (Study Visit 1) will last about 2 to 2 ½ hours. All other study visits will last about 1 hour.
3Will I be compensated for my participation in this study?
You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits and tasks you do complete according to the following schedule:
  • You will receive $25 for completing all of the on-site screening tests at Study Visit 1. In order to combat rising gas prices, you will receive an additional $25 for completing the initial screening visit ($50 total).
  • You will receive $75 for each completed visit; Study Visit 2 through Study Visit 7 ($450 total).
  • You will receive $5 a day for responding to daily surveys through eResearch. In order to receive compensation, you will need to answer all of the questions before you receive your next survey. Daily surveys will be sent once per day for approximately 89 days ($445 total).
  • If you return to the office for a 6-month CO reading you will receive an additional $75.
  • 4Who is funding the study?
    The study is being funded by a grant from the Foundation for a Smoke-Free World. The study investigator and research staff are being paid to conduct this study. The Foundation for a Smoke-Free World is an independent non-profit organization that receives funding from Philip Morris International (a company which manufactures cigarettes).


    For Future Studies

    Fill out our form below for more information

    Participant information is maintained in a volunteer database system and retained for future studies as they become available. Pertinent information is confidentially kept on file to aid in selecting highly qualified candidates for research studies.

    Participant Full Screen

    Why should I participate?

    Participants may gain access to new research treatments before they are widely available.

    Additionally, participants are compensated for their time and receive study-related products and medications at no cost. You may be among the first to benefit if the approach being studied is found to be helpful.