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    Our team of professionals are trained to conduct clinical trials for people who want to quit smoking.

    Our trials test medications, behavioral approaches and various combinations of both in an attempt to find the most effective smoking cessation treatment. Our staff is also trained to conduct behavioral counseling.

    The Embera Study

    The purpose of the Embera study is to see if using a combination of two medications may help you quit smoking. Both medications (metyrapone and oxazepam) are Food and Drug Administration (FDA) approved, but not specifically to help people quit smoking. Metyrapone is a drug used to test hypothalamic-pituitary ACTH function and oxazepam is a drug used to treat anxiety or alcohol withdrawal symptoms. The use of these drugs together is investigational and has not been approved by the FDA.

    Embera FAQ

    1What are the criteria to participate?
    • Between 21-65 years old and able to pass a urine drug screening.
    • Smokes at least 10 cigarettes per day.
    • Are not currently diagnosed with any serious medical or psychological conditions.
    • Have not used any electronic cigarettes, vapes, chewing tobacco, cigars, pipes, hookahs, or nicotine replacement therapy (nicotine patches, lozenges, gum, etc.) in the last 2 weeks.
    • Because these two drugs are not FDA approved to be used together, females must be unable to become pregnant during the course of this study. This means women must be post-menopausal or surgically sterile.
    • Must not have recently used any of the following: illegal drugs, investigation drugs, SSRIs, antidepressants, antipsychotics, opiates, biotin products, glucocorticoids (oral, inhaled, or topical), or joint injections.
    2How long is the study?
    Your participation in this study will last about 16-17 weeks and will include twelve (12) visits to the study center. This Screening Session (Study Visit 1) and Study Visit 3 will last approximately two to three hours, and all other study visits will last approximately one hour.
    3Will I be compensated for my participation in this study?
    Yes. You will be compensated up to $2,225 plus $5/day for completing daily surveys for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits you do complete according to the following schedule:
  • You will receive $25 for completing Study Visit 1.
  • You will receive $100 for completing Study Visit 2.
  • You will receive $150 for completing Study Visit 3.
  • You will receive $175 for completing Study Visit 4 through Study Visit 6 ($525 total).
  • You will receive $200 for completing Study Visit 7 through Study Visit 10 ($800 total).
  • You will receive $250 for completing Study Visit 11 and Study Visit 12 ($500 total).
  • You will receive $25 for participating in telemedicine contacts between visits ($125 total).
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of the questions before you receive your next text message.
    • 4Who is funding the study?
    The study is being funded by Embera NeuroTherapeutics. Inc. The study investigator and research staff are being paid by them to conduct this study. The Foundation for a Smoke-Free World paid for the manufacturing of the study drug. The Foundation for a Smoke-Free World is an independent non-profit organization that receives funding from Philip Morris International (a company which manufactures cigarettes).

    The COCO Study

    The main purpose of this research study is to compare the measured amount of carbon monoxide (CO) in your exhaled breath between two different CO monitors and compare these to the amount of carbon monoxide in your blood measured directly from a sample of blood from your vein. Both of the CO monitors being used in this study are approved by the United States Food and Drug Administration (FDA). Another purpose of this research study is to evaluate a new mobile app called eResearch. This app was developed by Rose Research Center to conduct remote research. .

    COCO FAQ

    1What are the criteria to participate?
    • Between 21-65 years old
    • Able to pass a urine drug screen
    • Daily cigarette smoker
    • Willing to use reduced nicotine cigarettes and an e-cigarette, both provided by Rose Research
    • No intention of quitting smoking in the next 30 days.
    • Must not have recently used any of the following: illegal drugs, investigational drugs, or chronic opioid use.
    2How long is the study?
    Your participation in this study will last about 1-2 weeks and will include a virtual visit and two in-person visits to the study center. The virtual Screening Session will last approximately one hour and will be done through a virtual meeting. Your first visit to our Center will last one to two hours and the other visit will last 15-20 minutes. You will also be asked to complete tasks from home using the app during the time between visits. These daily tasks should take about 15-30 minutes.
    3Will I be compensated for my participation in this study?
    You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits and tasks you do complete according to the following schedule:
  • You will receive a $10 Amazon gift card for completing this virtual screening.
  • You will receive $15 for completing the on-site screening procedures.
  • You will receive $100 for completing the first study visit.
  • You will receive $25 a day for completing tasks in eResearch. In order to receive this compensation, you will need to compete the task and respond to the questions in the workbook. All of these payments except one will be processed at your final visit. One of the tasks your complete in eResearch will prompt an immediate payment through the app.
  • If you are randomly selected to take home a screening kit you will be compensated an additional $25. This payment will be processed at your final visit.
  • You will receive $10 for completing the final study visit.
  • You will receive an additional $10 for completing the final task that occurs after the final visit.
    • 4Who is funding the study?
    The study is being funded by a grant from the Foundation for a Smoke-Free World. The study investigator and research staff are being paid to conduct this study. The Foundation for a Smoke-Free World is an independent non-profit organization that receives funding from Philip Morris International (a company which manufactures cigarettes).

    The CAST Study

    The purpose of this research study is to see if an investigational drug, called centanafadine can help you quit smoking cigarettes. An investigational drug is a drug that is being studied before approval by the United States Food and Drug Administration (FDA).

    CAST FAQ

    1What are the criteria to participate?
    • Between 21-65 years old
    • Desire to quit smoking cigarettes
    • Willingness to take study medications as directed
    • Currently smoke 10 or more cigarettes per day
    • Able to pass a urine drug test
    • No current serious medical conditions
    • No use of other tobacco products in the last 14 days (including cigars, pipes, hookahs, e-cigarettes, or nicotine replacement therapy.)
    2How long is the study?
    Your participation in this study will last 10 weeks and will include 6 visits to the study center. The Screening Session (Study Visit 1) will last approximately one to two hours, and all other study visits will last approximately one hour.
    3Will I be compensated for my participation in this study?
    You will be compensated for your time and inconvenience related to your participation in this study. If you do not complete the study, for any reason, you will be paid for the study visits and tasks you do complete according to the following schedule: The maximum compensation you may receive without unscheduled visits is $1,175.
  • You will receive $25 for completing Study Visit 1
  • You will receive $150 for each completed visit; Study Visit 2 through Study Visit 6 ($750 total)
  • You will receive $50 for completing the Follow Up call
  • You will receive $5 a day for responding to text messages. In order to receive compensation, you will need to answer all of the questions before you receive your next text message. Text messages will be sent once per day for approximately 60 days ($350 total)
  • You will receive $100 if an additional unscheduled visit is required
    • 4Who is funding the study?
    The study is being funded by the Otsuka Pharmaceutical Development & Commercialization, Inc.

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    For Future Studies

    Fill out our form below for more information

    Participant information is maintained in a volunteer database system and retained for future studies as they become available. Pertinent information is confidentially kept on file to aid in selecting highly qualified candidates for research studies.


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    Why should I participate?

    Participants may gain access to new research treatments before they are widely available.

    Additionally, participants are compensated for their time and receive study-related products and medications at no cost. You may be among the first to benefit if the approach being studied is found to be helpful.

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